Trikafta® granules
This product is manufactured by Vertex Pharmaceuticals and is a combination of 3 ingredients, ivacaftor, tezacaftor, and elexacaftor.
This product is taken orally.
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orally
Why is it prescribed?
Trikafta® is used in combination with similar medications to treat cystic fibrosis (CF) in patients 2 years of age and older who have certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
- This medication should always be taken just before or just after fat-containing food.
- Take each dose approximately 12 hours apart.
- If you miss a dose and it has been less than 6 hours, take it as soon as possible.
- If you miss a dose it has been more than 6 hours:
- If the missed dose was the morning dose, take the missed dose as soon as you can and do NOT take the evening dose that day. Take your next morning dose at the usual time
- If the missed dose was the evening dose, take your next morning dose at your usual time.
- Store at or below 30°C.
- To prepare the granules:
- Remove the packet from the wallet when ready to give.
- Shake the packet gently to settle the granules to the bottom of the packet.
- Tear or cut packet completely open along cut line.
- Pour all the granules of the packet into 5 mL (1 teaspoon) of soft food (e.g., puréed fruits or vegetables, yogurt, applesauce) or liquid (e.g., water, milk, breastmilk, infant formula, juice [except for grapefruit juice]) that is between 5°C to 25°C.
- Mix in a small container (such as an empty bowl). Look inside the sachet to make sure there are no granules left inside.
- After mixing, give within 1 hour. Make sure all medicine is taken. This is very important for it to work properly and be effective.
Alternatives
Other products that have the same ingredients as Trikafta® granules are •Trikafta® tablets ••Trikafta® tablets ••Trikafta® tablets •
See other products used in the treatment of •cystic fibrosis •
The recommended dose is:
- 2 to < 6 years:
- weighing < 14 kg: One packet of elexacaftor 80 mg/tezacaftor40 mg/ivacaftor 60 mg granules in the morning and one packet of ivacaftor 59.5 mg granules in the evening.
- weighing ≥ 14 kg: One packet of elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mg granules in the morning and one packet of ivacaftor 75 mg granules in the evening.
- ≥ 6 years
- See Trikafta® tablets
Various mutations of the cystic fibrosis gene block the "gates" that allow the flow of salt across the cell membranes. This causes mucus to become thick and clog the lungs. Trikafta® helps "open the gates" more often allowing more salt to pass through. The thick mucus is reduced and cystic fibrosis symptoms lessen.
Important potential side effects. These are not common but are possible:
- liver problems
- cataracts
- allergic reactions
Contact your doctor if any of these side effects persists or are bothersome:
- diarrhea
- stomach (abdominal) pain
- upper respiratory tract infections, including the common cold and the flu
- headache
- nasal congestion
- runny nose
- sinus congestion
- rash
- changes in blood tests
- Drive and use machinery with caution as you may feel dizzy.
- Do not take this medication if you are allergic to any part of it.
Take this medication with caution if you:
- have kidney problems
- have liver problems
The following medications may interact with Trikafta®:
- antifungals such as ketoconazole, itraconazole, posaconazole, voriconazole, fluconazole
- some antibiotics such as clarithromycin, erythromycin, rifampin, rifabutin
- some anti-seizure medications such as phenobarbital, carbamazepine, phenytoin
- some medications to treat diabetes such as repaglinide, glimepiride, glipizide
- digoxin
- medications used after a transplant such as cyclosporine, sirolimus, tacrolimus
- warfarin
- St. John’s wort
- products that contain grapefruit
Use in pregnancy and breastfeeding: Little is known about the safety of this medication when used in pregnancy and breastfeeding. Consult your doctor or pharmacist before use.