Symdeko™ tablets
This product is manufactured by Vertex Pharmaceuticals and is a combination of two ingredients, ivacaftor and tezacaftor.
This product is taken orally.
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orally
Why is it prescribed?
Symdeko® is used for the treatment of cystic fibrosis (CF) in patients 12 years of age and older who have certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
- This medication should always be taken just before or just after fat-containing food.
- Take each dose approximately 12 hours apart.
- Swallow the tablets whole. Do NOT chew, break or dissolve the tablets.
- If you miss a dose and it has been within 6 hours of the time you usually take it, take it as soon as possible.
- If you miss a dose and it has been more than 6 hours since the time you usually take it, skip the missed dose and take the next dose at your regularly scheduled time. Do NOT double your dose.
- Store at or below 30°C.
Alternatives
Other products that have the same ingredients as Symdeko™ tablets are •Trikafta® granules •Trikafta® tablets ••Trikafta® granules •Trikafta® tablets •
See other products used in the treatment of •cystic fibrosis •
The recommended dose for individuals 12 years and older is: one yellow tablet (tezacaftor 100 mg/ ivacaftor 150 mg) in the morning and one blue tablet (ivacaftor 150 mg).
Various mutations of the cystic fibrosis gene block the "gates" that allow the flow of salt across the cell membranes. This causes mucus to become thick and clog the lungs. Symdeko® helps "open the gates" more often allowing more salt to pass through. The thick mucus is reduced and cystic fibrosis symptoms lessen.
Important potential side effects. These are not common but are possible:
- cataracts
- allergic reactions
Contact your doctor if any of these side effects persists or are bothersome:
- nausea
- common cold
- headache
- dizziness
- nasal congestion
- Drive and use machinery with caution as you may feel dizzy.
- This medication may cause abnormal blood results. Your doctor will decide if you need blood tests.
- Do not take this medication if you are allergic to any part of it.
Take this medication with caution if you have:
- kidney problems
- liver problems
The following medications may interact with Symdeko®
- antifungal medicines such as ketoconazole, itraconazole, posaconazole, voriconazole, fluconazole
- some antibiotics such as clarithromycin, rifabutin, rifampicin, erythromycin
- some anti-seizure medications such as phenobarbital, carbamazepine, phenytoin
- warfarin
- some medications used to treat diabetes such as glimepiride, glipizide
- digoxin
- some medications used after an organ transplantation such as cyclosporine, everolimus, sirolimus, and tacrolimus
- St. John’s wort
- products containing grapefruit or Seville oranges
Use in pregnancy and breastfeeding: Little is known about the safety of this medication when used in pregnancy and breastfeeding. Consult your doctor or pharmacist before use.