Apo-Tadalafil PAH tablets

Apo-Tadalafil PAH tablets

This product is manufactured by Apotex Inc. using the ingredient tadalafil.

This product is taken orally.


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orally

Why is it prescribed?

Tadalafil is used to treat pulmonary arterial hypertension (PAH), which is high blood pressure in the arteries of your lungs.

  • Take 2 tablets together at the same time (for a 40 mg dose) at the same time of day. Do not divide the dose over the course of the day.
  • If you miss a dose, take it as soon as possible. If it is close to your next dose, skip the missed dose, and take your next dose at the regular time.
  • Apo-Tadalafil PAH can be taken with or without food.
  • Foods and beverages that contain grapefruit may cause low blood pressure if consumed while taking Apo-Tadalafil PAH.
  • Alcohol in combination with Apo-Tadalafil PAH may cause low blood pressure.
  • Store at room temperature (15 to 30°C).

Alternatives

Other products that have the same ingredient as Apo-Tadalafil PAH tablets are •Adcirca® tablets •Opsynvi® tablets •

See other products used in the treatment of •primary pulmonary hypertension •

The recommended dose is 40 mg taken once daily.  


Tadalafil helps the blood vessels in the lungs relax. This allows more blood to flow into your lungs and reduces the blood pressure in the arteries of your lungs.


Immediately seek medical help if you experience:

  • chest pain
  • an allergic reaction: difficulty swallowing or breathing, shortness of breath, wheezing, fever, skin rash, hives, swelling
  • a painful erection of the penis lasting longer than 4 hours in duration
  • sudden decrease or loss of hearing
  • a sudden decrease or loss of vision
  • temporary memory loss

Other possible side effects

  • headache
  • muscle pain
  • facial flushing
  • nausea
  • pain in the arms or legs
  • back pain
  • upset stomach or heartburn
  • nasal congestion

Do not take tadalafil if you:

  • are taking any medications that contain nitrates, which are used for chest pain; if you are not sure, check with your pharmacist
  • are taking any medications that are guanylate cyclase stimulators, such as riociguat
  • have had an eye disease called non- arteritic anterior ischemic optic neuropathy (NAION)
  • are allergic to any part of it

Use tadalafil with caution in:

  • pulmonary veno-occlusive disease (PVOD)
  • dehydration, which may occur if you are sick with fever, vomiting, or diarrhea or if you sweat a lot and don’t drink enough liquids
  • heart disease or previous heart attack
  • stroke
  • low blood pressure or uncontrolled high blood pressure
  • liver problems
  • kidney problems
  • sickle cell anemia
  • multiple myeloma, leukemia
  • retinitis pigmentosa

Avoid the following medications while on tadalafil:

  • nitrates, including nitroglycerin, isosorbide mononitrate, isosorbide dinitrate
  • verapamil or diltiazem
  • some antibiotic medications such as rifampicin, erythromycin
  • some antifungal medications such as ketoconazole, itraconazole
  • some medications used to treat HIV such as ritonavir, saquinavir
  • some antiseizure medications such as phenytoin, carbamazepine, phenobarbital
  • other medications used to treat PAH,  including bosentan
  • other similar medications, including sildenafil and vardenafil

Discuss with your doctor if you are taking:

  • medications to lower your blood pressure
  • doxazosin or other "alpha blockers"

Do not take products containing grapefruit as they can increase the effects of this medication. 

Use in pregnancy: it is not known if tadalafil has harmful effects on a fetus if taken during pregnancy and is generally not recommended.

Use in breastfeeding: it is not known if this medication can pass into breast milk. Therefore, breastfeeding is not recommended.