Why is it prescribed?
This medication is used as a first treatment option in non-small cell lung cancer that has spread to other parts of the body (metastasized) or for which surgery is not appropriate and is anaplastic lymphoma kinase (ALK) positive. Alectinib can also used for this type of cancer when crizotinib treatment has not been successful or tolerated.
Products that have this ingredient include •Alecensaro® •
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More common side effects; Contact your doctor if you experience these side effects and they are severe or bothersome.
- dry skin
- fluid buildup in arms, legs, ankles
- hair loss
- increased sensitivity to the sun
- metallic taste in the mouth
- muscle and joint aches or pain
- weight gain
Less common: Check with your doctor as soon as possible if any of the following side effects occur:
- numbness or tingling in hands and feet
- signs of anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- signs of muscle damage (e.g., unexplained muscle pain, tenderness or weakness, or brown or discoloured urine)
- slowed heart beat (e.g., dizziness, lightheadedness, fainting)
- vision changes (e.g., blurred vision, loss of sight, black dots or white spots in vision, seeing double)
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of lung problems (e.g., worsening or new difficulty breathing, shortness of breath, cough with or without mucus, fever)
- signs of tear in the stomach or intestines (e.g., severe stomach pain, fever, chills, changed in bowel habits)
Alectinib is a protein kinase inhibitor which helps stop cancer from making new cells if the cancer is caused by a defect in a gene called anaplastic lymphoma kinase (ALK). It helps slow down the growth and spread of non-small cell lung cancer (NSCLC).
Discuss use of alectinib with your health profession if you:
- are intolerant to lactose
- are younger than 18 years of age.
- are taking medicine to lower your blood pressure or control your heart rate.
- have a history of slow heart rate or fainting.
- have a history of heart problems including irregular heartbeat, heart disease and heart failure.
- have a history of problems with your gut, such as inflammation in the intestines(diverticulitis), a previous tear in your stomach or intestines or cancer that has spread to your gut.
There may be an interaction between alectinib and the following:
- beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
- grapefruit juice
- St. John's wort
Safety in pregnancy: Alectinib can be dangerous to the fetus. Both female and male patients on alectinib must use effective birth control during treatment and for at least 3 months after.
Safety in breastfeeding: It is not known if alectinib passes into breast milk. Talk to your doctor about breastfeeding concerns.