Medications

Mycobutin tablets   

This product is manufactured by Pfizer using the ingredient rifabutin.

This product is taken orally.


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orally


Why is it prescribed?

Rifabutin is used to treat tuberculosis and Mycobacterium avium complex (MAC) disease.


  • Do not stop taking Mycobutin® unless directed by your physician as this could cause the infection to return.
  • Take this drug at the same time every day.
  • Swallow the capsules whole with a drink of water.
  • If this medication makes you feel nauseous, you can take one capsule twice a day. In this case, take with food.
  • If you forget to take a dose, take it as soon as you remember, unless it is time for your next dose. Do not take a double dose to make up for a missed dose.
  • Store Mycobutin® at room temperature 

 


Alternatives

See other products used in the treatment of •tuberculosis •

The usual dosage is 300mg by mouth once daily or 3 times/week.


Rifabutin is an antibiotic that treats infections caused by germs (bacteria) called mycobacteria. Mycobacteria cause infections such as tuberculosis and Mycobacterium avium complex (MAC) disease. 


More common side effects:

  • Abdominal or stomach pain
  • bad, unusual, or unpleasant (after) taste in the mouth
  • belching
  • bloated or full feeling
  • change in taste
  • discoloration of the urine
  • excess air or gas in the stomach or intestines
  • headache
  • nausea
  • passing gas
  • trouble sleeping

Check with your doctor immediately if any of the following side effects occur:

  • Black, tarry stools
  • chest pain
  • chills
  • cough
  • diarrhea
  • fever
  • itching or skin rash
  • loss of appetite
  • painful or difficult urination
  • sore throat
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Do not use rifabutin if:

  • If you are allergic (hypersensitive) to this drug.
  • If you are allergic to any drug containing rifamycin.

Make sure you tell your doctor if you have any other medical problems, especially:

  • Diarrhea
  • Inflammation of the muscle
  • Uveitis 
  • Severe kidney disease

Drug Interactions:

The following drugs may interact with rifabutin:

  • medications to treat diabetes
  • acetylsalicylic acid (ASA)
  • methadone
  • warfarin
  • prednisone
  • medications to suppress the immune system like cyclosporine and tacrolimus
  • quinidine or digitalis (digoxin is okay)
  • dapsone
  • phenytoin (Dilantin)
  • medications to treat fungal infections like fluconazole, itraconazole, posaconazole, voriconazole, ketoconazole and miconazole
  • medications to treat viral infections like indinavir, saquinavir, ritonavir or amprenavir, fosamprenavir/ritonavir, lopinavir/ritonavir and tipranavir/ritonavir
  • delviradine
  • clarithromycin
  • birth control pills that have ethinyl estradiol and/or norethindrone.

Use in pregnancy: There is no human data available on safety in pregnancy. Animal studies suggest low risk.

Use in breastfeeding: There is no human data available on safety in breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

 


Page Last Updated: 05/10/2016