Why is it prescribed?
Topotecan is used to treat sensitive small cell lung cancer after failure of first-line chemotherapy (defined as recurrence at least 60 days after first-line chemotherapy).
Products that have this ingredient include •Topotecan Injection •
See other drugs used in the treatment of •small cell lung cancer •
More common side effects that do not require medical attention unless bothersome:
- appetite loss
- burning or tingling in the hands or feet
- nausea and vomiting
- redness or bruising at site of the injection
- temporary hair loss
Contact your doctor if any of the following side effects occur:
- abdominal or stomach pain
- sores or white spots on the lips, tongue, or inside the mouth
- unusual fatigue or weakness
The following side effects could indicate serious complications. Seek immediate medical attention if any of the following occur:
- black or tarry stools or blood in urine
- cough or hoarseness with fever or chills
- fever or chills
- irregular or fast breathing
- large welts on the face, eyelids, mouth, lips, or tongue
- lower back or side pain with fever or chills
- painful or difficult urination with fever or chills
- pinpoint red spots on skin
- puffiness or swelling of the eyelids or around the eyes
- shortness of breath
- unusual bleeding or bruising
- wheezing or tightness in chest
Topotecan belongs to the group of cancer-fighting medications known as antineoplastics. It kills cancer cells by interfering with the genetic material DNA, which is necessary for their growth and reproduction.
- Do not take topotecan if:
- you have severe kidney disease.
- you have severe bone marrow depression
- For both men and women: Do not conceive a child (get pregnant) while taking topotecan. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.
Drug interactions: There may be an interaction between topotecan and any of the following:
- grapefruit juice
- live vaccines (e.g., yellow fever, BCG, measles - mumps - rubella [MMR])
- pimecrolimus or tacrolimus
- protease inhibitors (e.g., atazanavir, indinavir, nelfinavir, ritonavir)
- quinine and quinidine
Use in pregnancy: There is a possibility of birth defects with topotecan. Effective birth control should be practiced while using this medication.
Use in breastfeeding: It is not known if topotecan passes into breast milk. At this time, breastfeeding is not recommended.