This product is taken orally.
Why is it prescribed?
Ivacaftor is used for the treatment of cystic fibrosis (CF):
- in children age 12 months and older who have one of the following mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene: G551D, G1244E, G1349D, G178R, G551S, S1251N, S1255P, S549N, or S549R
- also indicated for the treatment of cystic fibrosis (CF) in patients age 18 years and older with an R117H mutation in the CFTR gene.
Kalydeco® should always be taken with a fat-containing food to ensure you get the proper amount in your system. Each dose should be taken just before or just after fat-containing food.
If you miss a dose of Kalydeco® and it is within 6 hours of when you usually take it, take your dose as prescribed with fat-containing food as soon as possible. If you miss a dose and it is more than 6 hours after the time you usually take it, skip that dose only and take the next dose when you usually take it. Do not take 2 doses at the same time to make up for your missed dose.
Instructions for use:
- Each box contains 4 individual blister cards.
- There are 7 days of tablets for each blister card. Each blister card contains 14 tablets - 7 morning doses and 7 evening doses.
- You may cut along the dotted line to separate your doses from the blister card.
- Morning Dose: unpeel the paper backing from a blister card. Do not push the tablet through the paper backing because the tablets could break. Remove one tablet and swallow it whole with food that contains fat.
- Evening Dose: 12 hours after your first dose, unpeel the paper backing from another blister card to remove one tablet and swallow it whole with food that contains fat.
- Do not crush or chew the tablets
- Each box contains 4 individual wallets. There are 7 days of granules in each wallet. Each wallet contains 14 packets of granules - 7 morning doses and 7 evening doses.
- Finish all doses from one wallet before starting a new one.
- Morning Dose: Remove the first dose from the wallet. Hold the packet with cut line on top. Shake the packet gently to settle the granules. Tear or cut packet open along cut line. Carefully pour all of the granules in the packet into 1 teaspoon of soft food or liquid. Food or liquid should be at or below room temperature. Some examples of soft foods or liquids include puréed fruits or vegetables, yogurt, applesauce, water, milk, or juice (except for grapefruit juice). Mix the granules with food or liquid. After mixing, give within 1 hour. Make sure all medicine is taken. If mixed with food, the granules must not be stored for future use.
- Evening Dose: This dose should be taken 12 hours after your Morning Dose. Follow the same steps listed above under Morning Dose.
Store at 20-25 degrees C.
See other products used in the treatment of •cystic fibrosis •
Recommended dose for 6 years of age and weighing > 25 kg and up: 150mg twice daily (every 12 hours) with food containing fat.
Recommended dose for ages 12 months to 6 years:
- 7 kg - <14 kg: 50mg twice daily
- ￼≥14 kg to <25 kg: 75mg twice daily
Various mutations of the cystic fibrosis gene block the "gates" that allow the flow of salt across the cell membranes. This causes mucus to become thick and clog the lungs. Ivacaftor is a "cystic fibrosis transmembrane conductance regulator (CFTC) potentiator". The CFTR protein is a channel at the surface of the cells that allows the movement of particles such as chloride in and out of the cell, contributing to salt and water balance. Ivacaftor helps this CFTR protein channel or "open the gates" more often allowing more salt to pass through. The thick mucus is reduced and cystic fibrosis symptoms lessen.
Contact your doctor if any of these side effects persists or are bothersome:
• Stomach (abdominal) pain
• Common cold
• Runny nose
• Upper respiratory tract infection
• Changes in the type of bacteria in your sputum
• Nasal congestion
• Sinus congestion
• Sore throat
• Joint pain
Use with caution if you:
- have kidney or liver problems
- have cataracts
Possible drug interactions:
- ketoconazole, itraconazole, posaconazole, voriconazole, fluconazole
- some antibiotics such as clarithromycin, erythromycin, rifampin, rifabutin
- phenobarbital, carbamazepine, phenytoin
- midazolam, alprazolam, diazepam, triazolam
- cyclosporine, tacrolimus
- St. John’s wort
Use in pregnancy and breastfeeding. Little is known about the safety of this medication when used in pregnancy and breastfeeding. Consult your doctor or pharmacist before use.