Tobramycin Sulfate

Why is it prescribed?

Inhaled tobramycin sulfate can prevent worsening of and maintain stable status of patients with cystic fibrosis and chronic lung infections.

Products that have this ingredient include •Tobi® inhalation solution •Tobi® Podhaler® •Sandoz Tobramycin inhalation solution •Teva-Tobramycin inhalation solution •

See other drugs used in the treatment of •cystic fibrosis •

The most common side effects of inhaled tobramycin include:

  • cough
  • worsening of lung problems or cystic fibrosis
  • productive cough
  • shortness of breath
  • fever
  • sore throat
  • changes in your voice (hoarseness)
  • coughing up blood
  • headache
  • altered taste

Inhaled tobramycin can cause serious side effects, including:

  • hearing loss or ringing in the ears (ototoxicity). Tell your healthcare provider right away if you have hearing loss or you hear noises in your ears such as ringing or hissing. Tell your healthcare provider if you develop vertigo, difficulty with balance or dizziness.
  • worsening kidney problems (nephrotoxicity) - especially in people with known or suspected kidney problems. 
  • worsening muscle weakness - in people who already have problems with muscle weakness
  • severe breathing problems (bronchospasm). Tell your healthcare provider right away if you get any of these symptoms of bronchospasm:
    • shortness of breath with wheezing
    • coughing and chest tightness​


Tobramycin is an aminoglycoside antibiotic. It is used in the management of cystic fibrosis patients with chronic lung infections.

Do not use if allergic to aminoglycosides.

Tell your doctor before using inhaled tobramycin if you have:

  • Unusual difficulty in breathing with wheezing or coughing or chest tightness

  • Blood in your sputum (the substance you cough up)

  • Muscle weakness that lasts or becomes worse with time.

  • kidney problems

  • dizziness

  • Hearing problems

You should not take the following medicines while you are taking inhaled tobramycin:

  • Furosemide or ethacrynic acid

  • Urea or intravenous mannitol

  • Other medicines which may harm your kidneys or hearing

Use in pregnancy: Use only if risk outweighs benefit. Consult your docotor or pharmacist before use.

Use in breastfeeding: Use only if risk outweighs benefit. Consult your docotor or pharmacist before use.

Page Last Updated: 25/11/2015