Why is it prescribed?

Ambrisentan is used in adults to treat high blood pressure in the pulmonary arteries (pulmonary arterial hypertension).

Products that have this ingredient include •Volibris® tablets •Apo-Ambrisentan tablets •

See other drugs used in the treatment of •primary pulmonary hypertension •secondary pulmonary hypertension •

Side effects may include:

  • headache
  • nasal congestion (runny or blocked nose), red and sore throat, sinusitis
  • constipation, abdominal pain, nausea, vomiting  flushing (redness of the skin),
  • fluid retention (edema)
  • feeling tired or weak
  • palpitations (fast or irregular heartbeat)
  • vision changes, (blurry or other changes to vision)  ringing in the ears (tinnitus)
  •  symptoms related to low blood pressure, like dizziness or fainting.


Ambrisentan is a specific, competitive endothelin receptor antagonist, with ETA receptor selectivity.  It reduces high blood pressure by relaxing the pulmonary arteries. This makes it easier for the heart to pump blood to the lungs.


Ambrisentan should not be used in anyone less than 18 years of age.  At this time, safety and effectiveness have not been established in this age group.

Do not take ambrisentan if you:

  • are allergic to ambrisentan or any ingredients in the tablet
  • have liver disease or abnormal liver test results.
  • have a lung condition called idiopathic pulmonary fibrosis (IPF) 

 Talk to your doctor or pharmacist if you:

  • have or ever had liver problems
  • have a low number of red blood cells (anemia)
  • have swelling (edema)

Drug Interactions:  Check with your doctor or pharmacist if you are taking:

  • cyclosporine A 
  • digoxin
  • rifampin 
  • ketoconazole 
  • sildenafil, tadalafil 
  • warfari
  • omeprazole 
  • oral contraceptives 

Use in pregnancy and breastfeeding: Ambrisentan is not recommended for use if pregnant or breastfeeding.  Please discuss this with your physician and pharmacist.



Page Last Updated: 25/11/2015