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Combivent® Respimat®

This product is manufactured by Boehringer Ingelheim (Canada) Ltd. and is a combination of two ingredients, ipratropium bromide and salbutamol sulphate.

This product is inhaled into the lungs using the Respimat®.


Why is it prescribed?

  • Combivent® Respimat® is indicated for the treatment of bronchospasm associated with COPD.
  • Combivent® Respimat® is NOT indicated in children and adolescents under 18 years.

  • Each box contains 1 Respimat® inhaler and 1 cartridge, providing 60 puffs (30 medicinal doses). Physician samples provide 28 puffs (14 medicinal doses).
  • The color of the cap of the Respimat® inhaler is color coded to match the cartridge.
  • Never spray the medication toward the eyes
  • Before the inhaler is used for the first time, the cartridge must be inserted into the inhaler and then primed.
  • Prepare For First Time Use:
    • Step 1. With the orange cap closed, press the safety catch while pulling off the clear base. Be careful not to touch the piercing element located inside thebottom of the clear base.
    • Step 2. Write the discard by date on the label of the inhaler. The discard by date is 3 months from the date the cartridge is inserted into the inhaler.
    • Step 3. Take the cartridge out of the box. Push the narrow end of the cartridge into the inhaler. The base of the cartridge will not sit flush with the inhaler. About 1/8 of an inch will remain visible when the cartridge is correctly inserted. The cartridge can be pushed against a firm surface to ensure that it is correctly inserted. Do not remove the cartridge once it has been inserted into the inhaler.
    • Step 4. Put the clear base back into place. Do not remove the clear base again. The inhaler should not be taken apart after you have inserted the cartridge and put the clear base back.
  • Prime For First Time Use:
  • The following steps are needed to fill the dosing system the first time you use it and will not affect the number of doses available. After preparation and initial priming, the inhaler will be able to deliver the labeled number of doses (30 or 14). Proper priming of the inhaler is important to make sure the correct amount of medicine is delivered.
    • Step 5. Hold the inhaler upright, with the orange cap closed, to avoid accidental release of the dose. Turn the clear base in the direction of the black arrows on the label until it clicks (half a turn).
    • Step 6. Flip the orange cap until it snaps fully open.
    • Step 7. Point the inhaler toward the ground (away from your face). Press the dose release button. Close the green cap. Repeat Steps 5, 6, and 7 until a spray is visible. Once the spray is visible, you must repeat Steps 5, 6, and 7 three more times to make sure the inhaler is prepared for use. The inhaler is now ready to use. These steps will not affect the number of doses available. After preparation and initial priming, the inhaler will be able to deliver the labeled number of doses (30 or 14).
  • Daily Dosing:
    • Step A. Hold the inhaler upright with the orange cap closed, so you do not accidentally release a dose of medicine. Turn the clear base in the direction of the black arrows on the label until it clicks (half a turn).
    • Step B. Flip the orange cap until it snaps fully open. Breathe out slowly and fully, and then close your lips around the end of the mouthpiece without covering the air vents. Point the inhaler to the back of your throat. While taking in a slow, deep breath through your mouth, press the dose release button and continue to breathe in slowly for as long as you can. Hold your breath for 10 seconds or for as long as comfortable. Repeat Step A and Step B so that you get the full dose. Close the orange cap until you use the inhaler again.
  • Helpful Hints for Daily Dosing: If the inhaler has not been used for more than 3 days, spray 1 puff toward the ground to prepare the inhaler for use. If it has not been used for more than 21 days, repeat Steps 5, 6, and 7 until a spray is visible. Then repeat Steps 5, 6, and 7 three more times to prepare the inhaler for use.
  • The dose indicator shows approximately how much medicine is left. When the pointer enters the red area of the scale, there is enough medicine for 7 days (30 dose product) or 3 days (14 dose product). This is when you need to refill your prescription.
  • Once the dose indicator has reached the end of the scale, all puffs have been used and the inhaler locks automatically. At this point, the base cannot be turned any further.
  • Throw away the Combivent® Respimat® inhaler 3 months after insertion of cartridge into inhaler, even if all the medicine has not been used, or when the inhaler is locked, whichever comes first.
  • Store at room temperature.


Other products that have the same ingredients as Combivent® Respimat® are •Teva-Combo Sterinebs ••Teva-Combo Sterinebs •

See other products used in the treatment of •allergic rhinitis •asthma •bronchitis •bronchospasm associated with COPD •chronic bronchitis (COPD) •COPD •emphysema (COPD) •hay fever •perennial rhinitis •rhinitis •runny nose •seasonal rhinitis •exercise-induced bronchospasm •

  • The recommended dosage of Combivent® Respimat® in adults is one inhalation four times a day when needed. 
  • Patients may take additional inhalations as required; however, the total number of inhalations should not exceed six in 24 hours.

Combivent® Respimat® is a combination of two drugs that are bronchodilators: ipratropium bromide (an anticholinergic) and salbutamol (a beta-agonist). Combivent® Respimat® works by relaxing the muscle surrounding the bronchi (airways in the lungs) and therefore helps to ease breathing problems.

  • Side effects may include:
    • wheezing after inhalation
    • headache, dizziness
    • nausea (feeling sick), digestive problems like constipation, diarrhea and vomiting
    • muscle problems such as cramps, weakness, pain, feeling weak, tremor (shaking)
    • feeling nervous
    • mental disorder
    • impaired voice sounds
    • increased sweating
    • bronchitis and upper respiratory tract infection (a cold)
    • throat irritation, cough, dry mouth or throat, bad taste - sucking on a sour candy or rinsing your mouth may help.

  • The solution is intended for inhalation only.
  • Avoid getting the spray into your eyes. This may result in eye pain and/or discomfort, temporary blurring of vision, and/or colored images in association with red eyes. Should any of these symptoms develop, consult a doctor immediately.
  • BEFORE you use Combivent® Respimat® talk to your doctor or pharmacist if you:
    • are having treatment for a thyroid or adrenal gland condition
    • are having treatment for high blood pressure, angina, or a heart problem
    • have diabetes
    • have low levels of potassium in your blood (hypokalemia), especially if you are taking:
      • drugs known as xanthine derivatives (such as theophylline)
      • steroids to treat asthma
      • water pills (diuretics)
    • have eye problems, such as glaucoma, or eye pain
    • are taking any other medications including eye drops or any medications you can buy without a prescription
    • have difficulty in urination
    • have enlarged prostate
    • have any allergies or reactions to foods or drugs
    • have a history of convulsions (uncontrolled shaking or seizures)
    • have liver or kidney disease
  • Contact your doctor immediately if:
    • you require more than 1 daily dose (4puffs); the maximum daily dose is 6 puffs
    • your shortness of breath becomes worse
    • you don't get the same benefit from your medicine as you did before
    • you have breathing difficulties and chest pain
    • you experience difficulty with urination
  • Combivent® Respimat® may cause dizziness, difficulty in focusing the eye, dilated pupils, and blurred vision. You should not drive or operate machinery if this occurs.
  • The use of Combivent® Respimat® may test positive for performance enhancement (doping) in athletic competition.
  • Use in pregnancy: Considered safe to use in pregnancy, but consult your doctor or pharmacist before use.
  • Use in lactation: Considered safe for use in breastfeeding, but consult your doctor or pharmacist before use.