Alpha 1-antitrypsin

Why is it prescribed?

Alpha1-antitrypsin is indicated for the treatment of congenital alpha1-antitrypsin deficiency in adults who have developed emphysema.

Products that have this ingredient include •Prolastin-C® •Zemaira® •

See other drugs used in the treatment of •congenital alpha1-antitrypsin deficiency •

Alpha1-antitrypsin replacement therapy is usually very well tolerated. The following side effects may occur:

  • fever
  • lightheadedness
  • dizziness
  • flu- like symptoms
  • allergic-like reactions
  • chills
  • trouble breathing
  • abnormal heartbeat
  • changes in blood pressure
  • chest pain

If you experience any of the above side effects, contact your health care provider.

Alpha1-antitrypsin is a naturally occurring protein in the body which protects the lungs. Alpha-1 antitrypsin deficiency (AAT deficiency) is an inherited condition that raises your risk for lung and liver disease.

Symptoms of AAT deficiency include:

  • Shortness of breath and wheezing
  • Repeated lung infections
  • Tiredness
  • Rapid heartbeat upon standing
  • Vision problems
  • Weight loss

Therapy with alpha1-antitrypsin restores blood levels of this protein to a desired level. 

  • Alpha1-antitrypsin is made from human blood and therefore carries the risk of transmitting some viruses or illnesses.  Discuss this risk with yor physician.
  • Alpha1-antitrypsin must only be given by the intravenous route.
  • You should not use this medication if you are allergic to albumin or to any ingredient in the formulation or component of the container.
  • You should not use this medicine if your body does not make enough immunoglobulin A (IgA), which could cause you to have an allergic reaction to blood products that contain IgA.

Use in pregnancy: It is not known whether this medication can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. It should be given to a pregnant woman only if clearly needed.

Use in breastfeeding: It is not known if this medication is passed into breast milk.  Consult doctor or pharmacist before using


Page Last Updated: 25/11/2015