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Tezepelumab

Why is it prescribed?

Tezepelumab is used on a regular basis to treat severe asthma in people 12 years of age and older.  It is used with other asthma medicines when those medicines are not adequately controlling asthma symptoms.

 

Products that have this ingredient include •Tezspire™ •

See other drugs used in the treatment of •asthma •

More common:

  • Sore throat 
  • Redness, swelling, and pain at injection site
  • joint pain
  • rash

Tezepelum may cause allergic reactions. Symptoms of a mild allergic reaction can include:

  • skin rash
  • itchiness
  • flushing

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

  • swelling under your skin, typically in your eyelids, lips, hands, or feet
  • swelling of your tongue, mouth, or throat
  • trouble breathing

Call your doctor right away if you have an allergic reaction to tezepelumab, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.


Tezepelumab works by blocking a protein involved in immune and allergic responses that cause airway inflammation. This protein is called thymic stromal lymphopoietin (TSLP). By blocking TSLP, tezepelumab reduces levels of certain proteins and cells that cause airway inflammation.


Remember that this medication is not a rescue medicine and should not be used to treat a sudden asthma attack. If you have a sudden asthma flare-up, you should use your rescue medication as prescribed by your doctor.

Do not use if you’ve had an allergic reaction to tezepelumab or any of the ingredients in this product.

Do not use this medication if you have a parasitic infection as tezepelumab may weaken your ability to fight off these types of infections.

Drug Interactions:

  • at this time there are no known interactions with tezepelumab

Use in pregnancy: At this time, it is not known how tezepelumab affects pregnancy.  Discuss use with your health care provider

Use in breastfeeding: Tezepelumab does pass into breastmilk. Discuss use with your health care provider