Why is it prescribed?

Fluconazole is used to treat many fungal infections. This material will be limited to the treatment of candidiasis (yeast) infections of the mouth, throat and esophagus (food pipe).

Along with its needed effects, fluonazole may cause some unwanted or undesirable effects. Generally, fluconazole is well tolerated and many people will not experience unwanted effects. The frequency and severity of these effects is dependant on many factors including dose, duration of therapy and individual susceptibility. In general, fluconazole is well tolerated. Possible unwanted effects include:

  • nausea
  • vomiting
  • diarrhea
  • headache
  • skin rash

Fluconazole is an antifungal agent. It works by interfering with the formation of the fungal cell membrane.

Fluconazole should be taken exactly as prescribed. If you experience a rash, yellowing of skin or eyes, nausea, weakness, difficulty breathing or facial swelling contact your doctor immediately.
Drug Interactions: It is important to tell your doctor and pharmacist about any prescription or over-the-counter medications you are taking to help avoid any serious drug interactions. The dose of one or both medications may need to be altered or a new drug may be prescribed. In some cases, one of the drugs may have to be discontinued. The following drugs and drug classes have been known to interact with fluconazole.

  • acid blockers (e.g. cimetidine)
  • rifampin
  • warfarin (e.g. Coumadin®)
  • cyclosporine (e.g. Neoral®)
  • theophylline (e.g. Theo-Dur®)
  • phenytoin (e.g. Dilantin®)
  • hydrochlorothiazide
  • diabetes medication (e.g. glyburide)
  • oral contraceptives (e.g.Triphasil®)
  • zidovudine

Use is not recommended in the following situations:

  • allergy to fluconazole or any component of the preparation

Caution is recommended in the following situations:

  • kidney disease
  • liver disease
  • allergy to other azole antifungals (e.g. ketoconazole)

Use in pregnancy: If you suspect that you may be pregnant contact your doctor.
Use while breastfeeding: It is likely that fluconazole does pass into the breast-milk. Consult your doctor or pharmacist before use.

Page Last Updated: 25/11/2015